Alias:11a;amicin;AZOMYCIN;ro05-9129;AZOMYCINE;2-NITROMIDAZOLE;2-nitro-imidazo;2-Nitroimidaxole;WLN: T5M CNJ BNW;2-NITROIMIDAZOLE
Melting point: 287 ° C (dec) (lit.)
Boiling point: 211.75 ° C
The refractive index: 1.4264
Storage conditions: Refrigeration
Solubility: NH4OH: soluble50mg/mL, the clear, yellowtoorange
Color: Lightyellowtokhaki – green
Chemical Properties :Light yellow crystal. Melting point 283℃ (decomposition). Soluble in methanol, ethanol, acetone, ethyl acetate, insoluble in ether, chloroform
The intermediate of Misonidazole, an oncology radiosensitizer, is used as an organic synthesis intermediate.
It is used to prepare nitroimidazole-substituted boric acid as a precursor for hypoxic tissue imaging. It is also used to prepare site-available selective radiosensitizers for tumors rich in estrogen receptors.
Nitroimidazole (2-nitroimidazole) is the basic raw material for the synthesis and manufacture of nitroimidazole compounds in electronophilic radiosensitizers. N-substituted derivatives prepared from 2-nitroimidazole have been used as anti-tumor radiosensitizers in clinical studies. 2. Chemicalbook-based nitroimidazole is an important intermediate for a variety of radiotherapy sensitizers for tumors, such as Misonidazole, pimonidazole, etanidazole, etc.
Background: Malignant tumor is a common disease that seriously threatens human life. About 70 to 80 percent of these tumors require radiation therapy. Radiosensitizers have attracted much attention in radiotherapy because of their ability to increase the sensitivity of tumor cells to radiation. 2-nitroimidazole is an important intermediate for a variety of radiotherapy sensitizers for cancer, such as Misonidazole, pimonidazole, etanidazole, etc. 2-nitroimidazole cannot be made by direct nitrification of imidazole, which results in 4(5) -nitroimidazole, but not 2-nitroimidazole.
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